Yes, I bought a D800, and files that open to 125 - 150 MB are no fun to edit. Its hard to imagine what editing a 200 - 250 MB file would be like.
The files open so large due to the huge amount of noise in any image over about ISO 800. NEF is a compressed file, but they are uncompressed in order to edit them. I tried editing 1500 shots that I took at high ISO over a couple of nights. I had to use a ton of NR on them, and that took minutes per image to run.
I sold the D800 and bought a 5D MK III, it is much better for high ISO photography. The D800 is great at ISO 200, assuming that you buy lenses that can resolve the high MP, and that you use a tripod or very fast shutter speed. Its difficult to actually get the high resolution possible, many users do not and give up.
I have the 5DIII and both the D800 and D800E. If you have some Nikon glass that you would like to sell because you have sold your D800, please let me know. I use Photoshop CC and Bridge. The actual file sizes on disk (NEF) are less than 50MB and no where close to what you are quoting unless you are talking about the resulting photoshop saved PSD file with all the layers that are not flattened. Perhaps your computer is slow.
I have been very pleased with the resolution of Nikon glass and very much love the 14-24. Since I am a landscape guy I use ISO 100 mostly and here is where I find the D800 surpassing anything in the Canon line (most of which I still own). I find the raw files very easy to edit with Photoshop CC and have developed a very efficient workflow. It is true I am not a high ISO lover since my applications don't need it. Most of my prints that I do myself are 24 x 36 or larger.
Someday, if Canon comes out with a competitive camera, including the improved dynamic range of the D800 sensor over the Canon sensors, I really would like to shoot my Canon glass again because I really think the Canon tilt-shift lenses are a kick. Also Nikon supertels are heavier than Canon equivalents but then Canon is so much more money. I'm sure Nikon will catch up by decreasing weight and raising their prices just like Canon did.