I've never heard of hugin software, I'll have to check it out. I use autopano giga for all of my stitching, and shoot plenty of landscape and lifestyle pictures with on average of 15-40 shots per image anywhere from 28-300mm.
Things to keep in mind
1. How much is it worth, is it an amazing shot and taking the time to collect all these 300mm shots is worth it, or...
2. Always over shoot the outer frame of your panoramas. I can't stress this enough. Ill have a vision of what I want hanging on my wall, and then when I get back and stitch them together there isn't enough edge room for the composition I had in mind.
3. Content-Aware fill cannot fix everything
4.main basics - Set whitebalance to something other than auto, avoid lens flare at all cost, always overshoot, use a tripod if you can, check your focus before you start shooting and switch to MF to avoid accidents, keep close objects at equal distances away from you in wide panoramas (two support pillars in a 360 garage panorama, make sure you are an equal distance between them, etc)
I'd list more but I'm on a shoot this week and need some sleep. my flickr http://www.flickr.com/photos/shawnroach/
contains plenty of good examples.