I'm no pro, but being a freshman this coming summer, 22 megapickles is definitely enough for me.
I have been saving up for a full frame for a while, and whilst 5D2 is a bargain, my experience with 7D's AF and made me pretty sure that 5D2's isn't enough. So basically my wishlist was a 5D with a better AF, which is answered with the 5D3.
Now, why is this enough (or even ideal) for me? I will be stepping up from a 500D, which has 15 megapickles. I have no problem with it, so I doubt I'll have problem with a few extra pickles. On the other hand, D800 has too much for me, my laptop and my hard drive to handle. Note that I will be a college student, which means I do not have access to powerful processing desktops. Not to mention it will be a big selling point, thus making the price tag even heftier.
I hope this makes sense at all.