As far as the NR/sharpening goes, mine is pretty simple. In Capture One 6 Pro, import RAWs using a predefined profile I built for 50D and then zoom 400% on an area with small details, usually the eyes since I'm primarily a people shooter. Adjust as needed and apply local contrast while at 400%. Pan to dark areas to verify NR. I tend to lean on CO's "surface NR" and pull back "(regular) NR" as much as possible (which usually comes out about 1/3 NR slider 2/3 surface NR slider). The "color NR" value sent from the camera is usually right. For sharpening I tend to stay around values of 400/1.1/1 for the 50D and reduce the radius if hair doesn't look right, then increase threshold if it still isn't right. Add a hint of fine grain. Zoom out to normal and tweak local contrast as needed. This method is very fast and effective for me. It's interesting just how inter-dependent these particular functions are and it took some experimenting to find the sweet spot and fast workflow.