This morning I've tried this one. I focussed on the drop, but the top of the flower isn't sharp at all. What's wrong now.
Iso 500 - f/6.3 - 1/30
Still not enough depth of field.
If you are using a macro lens, depth of field is measured in millimeters and smaller. In order to work within the space allowed, you would need to keep the camera sensor plane parallel to the flower bud in your picture.
The distance from the base of the bud to the sensor would have to be the same as the distance from the tip of the bud to the sensor. Focus maybe halfway into the water drop, and you will see more "in focus" or "sharp". But, the sides of the bud that curve away would become "unsharp".
The only other alternatives are focus stacking or a tilt-shift lens.
If you focus stack, you will need a tripod and rail setup with a micometer style adjustment to move the camera and lens in and out so you do not touch the focusing adjustment on the lens (AF off). Changing the focusing with the lens would alter your field of view.
There are people here that could offer a much more in depth
answer to your question, but that's how I understand it.