I'd suggest that you buy or bowwor a good book on Lightroom. There are many very subtle things that are easy to miss using a learn as you go method, or by asking on forums.
I generally apply lens corrections as I import along with different NR levels according to ISO. First set the import parameters in preferences, then tweak settings in a image for a particular ISO level, This can include NR, lens correction, and many other settings.
Now select Develop/Set Default Parameters and save the parameters for the selected camera model or even body at that ISO. Now, when you import a image, each image with that ISO from that camera will use the setting. You can also click reset for other images, and the parameters will be applied to that image if it was from the camera and ISO specified.
It takes a few minutes, but you can setup parameters that differ by ISO and camera body, or make them all the same for a given camera model. If you have two 5D MK III's, you can optimize imports for each one. There are always small differences between cameras of the same model, and this will help make them more alike.