Thanks guys, that kinda answered my question. Just to clarify though, it would be a fairly static setup. The 430 is sitting on the 5DII on TTL and the 580 is separate from the rest (and not within optical reach, that's why I can't go wireless without extra triggers). The 580 will be on full manual, synced through PC with my 5DII. I was just wondering if the PC sync port would give signal if a TTL flash is mounted on the hotshoe. And "yes" seems to be the answer.
I really envy those who have 600EX-RT lol.