Two Lowe Pro Rollers - one large one, a 200, holds a spare body, 5 lenses, an extender, spare batts, seldom used flash, cleaning gear, etc. The smaller of the two is a Lowe Pro Attache 50 roller. It carries a 5D3 body with lens attached, usually the 24-105, one other lens that changes depending on where I'm going or where I was last, a charger, cleaning gear and a couple filters, e.g. polarizer and ND. The Attache 50 is my "walking around bag" and the larger is the storage unit. I take both along on long road trips, but usually only the smaller one on day trips.
With my age and arthritus, I have trouble carrying the weight without some help and these two bags are perfect. When needed, the larger bag also accommodates the pod in a strap-on kind of device that came with the bag. I keep plenty of dessicant packs in both bags. Then there's the shelf in the closet . . .