I know I'm late in the game for posting, but I went for the 6d. The image quality is super for what I like doing. Candid shots, event/fluff work, family and friends and everything else.
I upgraded cause I was tired of my old camera not doing what I wanted it to do and the image quality. Couldn't afford the 5dIII, I saw the deals and was tempted. I had to realize what I can afford. So I went for the 6d for the lighter body and low light capabilities.
I have big hands and don't have a problem with the 6d layout. I really like it. I can adjust the top settings and the back buttons with my index finger and thumb while looking through the view finder. The outer points are pretty good in my opinion, but I'm not a tester.
With the 70-200 2.8 non IS, the focusing is super fast. I'm really happy for what I can do with the camera. The 24-105 is my dedicated lens. Its a great combo for a lot of things I shoot.
What ever you decide, you can't go wrong.
Here is a sample from my 6d just walking around by the Berkeley Pier.