100L F/2.8 IS + LR4 (Rocking LR3 right now)
135L F/2 + Set of Extension Tubes
100 F/2.8 USM + 85mm F1.8 + 40mm F.28
I have a 24-105 and I have the 100mm f/2.8L IS Macro. I really like my 24-105, but I think it does get a touch soft at 85mm+. I think the 100mm is really sharp at 2.8 and I've taken some nice portraits and actions sports photos with it. It is my lens of choice when I can adjust my distance.
Having said that, I do a lot of portrait style photography... and I used to use the 50mm f/1.8, then upgraded to the 50mm f1.4 and the 100mm just blows both of them out of the water in regards to bokeh. I have heard the 135 is that much better, so I really do plan on getting one of them, but I'm not sure that will happen anytime soon (as I plan on getting a 5d mkiii and a 70-200mm f/2.8L IS).
As for the Macro, I'm quite pleased with the results. I don't do a ton of macro photography, but I have a few shots that I really like.
As for the third option... I just can't go back to non-L glass. I know the performance is solid, but when I have a shot that I absolutely love, I want to know that it could not have been any better.
I have LR4 right now... and I guess I didn't realize there was a sufficient reason to upgrade. Actually I'm a LR novice, so it is quite possible one is substantially better than the other.