So just to be clear, I have similar issues and I have tried with XP win7-32 bit and Win7-64bit. It's not specific to the MAC environment, though the MAC environment does pose it's unique issues. Win has its own unique issues especially with the .net framework.
Most of the issues I see here and what I am experiencing are with the analysis part. Yes I have had some crashing and some connectivity issues that require closing everyhting out and starting over but the majority has to do with analysis of the images.
I'm sorry to hear about the frustrations you are experiencing Rienzphotoz. I've been through exactly what you are going through. Same computer, same camera, with at least one of the same lenses. Your problem is the MAC operating system. Once I switched to a Windows operating system I never had a problem with it ever again.
Reikan FoCal is an AWESOME tool that is NOT completely stable on all MAC platforms yet. I love it and don't regret buying it, or what I have to do to utilize it.
When I stated that the MAC platform is not completely stable, I was not suggesting that the Microsoft platform is.
I am uniquely qualified to comment on the OP issues based on the fact that I had the exact same problems with the exact same gear. After installing the program on my Windows 7 64bit virtual machine, the issues went away and have never returned.
There's a big difference between the occasional need to restart the program, and the inability to complete any of the tests.
I installed and tried it on my windows PC ... but the error messages still continue.
According to Reikan website, "Fully Automatic" mode can be used for 5D MK III but FoCal will provide prompts for the user ... however, "Fully Automatic" mode just does not work, it just ends up either crashing or comes up with error messages. According to Reikan 5D MK III is to be used in "MSC" mode, but no such mode exists in version 1.8 or 1.9.
So I used it on "Semi-Automatic Mode".
I also tried to check my Nikon D7100+35mm f/1.8 lens but I still faced frustrating new errors ... first it said "Cannot validate camera information - please ensure your setup is correct and the lens is not in manual focus mode", so I closed and restarted FoCal (without making any changes to my camera/lens settings) and everything seems to work properly till it gets to DeFocus part then it either crashes or says "LiveView Timeout".
After 11 attempts, since yesterday afternoon, I finally completed one full test in "Semi Automatic" (using 5D MK III
+ 50mm f/1.4), it gave me a result of +1 for the lens. But after having failed (with error messages) in all other tests (9 in all) with other Canon lenses & Nikon lenes (using D7100) I tried again with 5DMKIII + 50mm f/1.4 ... once again the software quit on me 4 times and it finally gave me a result of +6 ... a total of 20 test attempts, with 2 successful completions but with different results ... now I'm really confused.
My limited experience, of 1 week of frustrations with FoCal, tells me that it is not an easy to use software if you are trying to test 5D MK III or a Nikon D7100 ... but Rekien website claims that it is very easy ... maybe Reikan has a different threshold for "easy" or I'm just not very bright.
Another problem with FoCal is that there isn't much on the internet to help guide and whatever that is out there is outdated and in keeping with the latest version ... same applies to Rekien's own website. Also, their help desk takes almost 3 days to respond to queries ... so all that does not help make it easy to use this software on my 5D MK III or Nikon D7100.
Since I've already spent money on it I will continue to test it every weekend and continue to update my experience with FoCal (unfortunately so far FoCal has done nothing for any of my lenses)