Sharpening is almost always a good decision, especially right before you print. Some of the top photoshop guru's say you should first go into your image, run a noise program to remove noise (if any depending on ISO), then run a low localized sharpening to taste. If you have CS5 or CS6, the sharpening tool in the tools panel is good enough for localized sharpening (eyes, mouth, nostrils, etc...) Then do whatever other manipulations, if any, you wish to do... Then once it's ready to print, sharpen again, and then print. When you print, ink spreads (dot gain) and so even the crispest photo MAY look a hint softer than you would have expected at 100% viewing on photoshop... The second sharpening combats this, if desired. RAW or JPEG, that really doesn't matter. Once a raw file is processed, they basically are the same... Jpeg may not be as crisp or may be noisy, depending on your settings, but really it doesn't matter either way. Lastly, there are other plug-ins you can get like topaz detail or such where it can add that bit more detail from your image and add that bit more sharpening that you may or may not like... They give you options for small details (noise level), medium details, and large details... so you can determine which details are important to you. Hope that helps.