I agree with interpilot: keep your main hiking bag to carry all your stuff in, and then bring a separate, much smaller daybag for your camera in case you ever want to just bring your camera and not the rest of your stuff. frankly, if you're a really dedicated shooter, you might not even need the daybag if the camera is truly at your fingertips 100% of the time. just depends on how much of the focus is on hiking, and how much is on photography. when I went to Ecuador I realized I really only needed a bag to bring swap lenses as there was nearly zero time without camera in hand.
I'm not sure what sort of superhuman M4X is, but I have no idea how he managed to do a trip with a duffel bag. a duffel bag even full of clothes becomes a pain in the butt to haul around because of the way it's carried around your neck and shoulders. and it's not a strength thing. I've done 3-day hikes with 50+ lbs of gear on my back, and I'd rather do it again than carry a duffel bag continuously for 3 hours.