My Think Tank Retrospective bag is absolutely fantastic. I've got the Pinestone 7 and it really holds everything I need: 6D, lots of smaller primes, and a whole bunch of odd bits stuffed in the other nooks & crannies. It's the perfect companion if you have a 10" tablet or a smaller ultrabook that will fit in the laptop pouch (which also holds magazines when there's no computer in there).
What I find really great about this bag is that it has forced me to rethink the gear I take with me. I have a bunch of other bags, but they're all either too small to fit anything useful besides maybe one extra lens, or once I fill them up they're too big & heavy & clumsy to access. So the end result was either wanting more lenses, or not bothering to drag all my stuff with me wherever I go when I'm on a trip as it's too heavy.
The retro 7 is really the right size; big enough to hold a reasonable amount of stuff & small enough to be practical. It forces me to think about the gear I *need* for the trip & take only that. This usually ends up being the 6D with the 24-105L on it and whatever primes I think I'll need, depending on what I'll be shooting & how much walking there is to be done. I keep all the stuff that I don't need when I'm shooting (chargers, cables, readers, etc) in a lens bag in the front & just pull it out & leave it in the room where I'm staying.
It's super easy to access. Even taking a tablet or computer out to check a map or mail is really fast. And no one thinks its a photo bag. Obviously I'm pretty psyched about it.