I haven't given it a good full test yet, but I am enjoying backyard bird photography with the 5D3, 100-400 and the 1.4X II. Focus is reasonably quick, and it is pretty accurate. The image quality is decent, not on par with the big primes, but definitely not bad either. Occasionally, I find some weird pattern to the bokeh, but I think that's more a fault of the 100-400 than anything.
The true test will come with using some of the bigger glass and teleconverter combinations to see how it works for very long distance shooting. I've found, though, that stacking teleconverters does take its toll on IQ so that the results will be slightly less than optimal.
I'm really considering a 500/4 II in the future - somewhat light, and compatible with the 1.4X or the 2X teleconverters to give a variety of very long lens capability without the heft of the 400/2.8.