Hyperfocal focusing is a sure fire way to ensure nothing of any importance is in focus. Focus on the subject and get that pin sharp, that is where peoples eyes will be drawn to because, one, it is the subject or anchoring point, and two, because it has the sharpest focus.
But if this kind of thing is important to you then I would strongly recommend in your near future renting a 17 TS-E. Using a little tilt and getting everything pin sharp at f4 is a wondrous thing and is truly unfake-able in Photoshop. Use it at f8 or 10 and you get zero diffraction, everything pin sharp and unmatchable image quality.