Take a look at Thinktank, Gura Gear and LowePro, I have been looking for a good bag for quite some time and it came down to Thinktank Streetwalker Pro, Gura Gear Bataflae, and LowePro protrekker series. My needs may be different from yours but I was looking for a bag that could carry one large lens with pro camera, plus 3-4 lenses. I needed something that could be taken on small airplanes as well as large airlines and a backpack style that I could carry on long nature excursions.
I chose the Streetwalker Pro in the end due to size (much smaller and still able to carry a sigma 120-300 f2.8 on a 1dIV) and price...about half that of the other options.
Good luck on your search, that perfect bag always seems to be just around the corner.