I started weddings with the 24-70 2.8 and 70-200 2.8. I've since added the 35mm 1.4 and the 85mm 1.8. I shoot with two bodies with a 3rd for backup, all FF. Each body has a speed light with a radio attached to trigger my AB Einstein.
I use the zooms for reliability/versatility and incorporate the primes for creativity. I prefer using the primes, but there are always circumstances that require the quick response of the zooms (ie staying out of the way during ceremony, speeches etc or diving into the crowd on the dance floor).
For group shots I never open up further than F4 and will try to get as much DOF as possible.
Lighting wise, more often than not venues require additional light beyond just high ISO, wide apertures, and on camera flash...hence the extra strobe as a room light. It still requires a lot of attention and adjustment throughout the event. There is no "set it and forget it" situation unfortunately.
It's part of why I enjoy weddings. They are fast paced challenging situations that are always pushing me to squeeze the best out of the situation. There are still plenty of times that have me cursing under my breath, but I keep coming back for the times I really hit it under those tough circumstances. It's a bit of a rush....but it ain't easy.