Interesting application but dithering has been used to suppress digitisation artefacts in astrophotography for years.
The pixels on this sensor are 6.0 microns on a side. Implicit in this is the requirement that the lenses can resolve acceptably to pixel level.... something like a 8 micron spot. Since this translates to MTF50 of ~125 lp/mm, I am sceptical about the technique being of much value. Of course, it's possible to apply sharpening algorithms and there is information to work on.
Secondly, if anything is to be achieved, critical focus will be essential. Some sort of f/8 tilt shift lens might work here.
Third, it does require the tripod to be astonishingly stiff. Assuming an 80mm lens, the pixels subtend .006/80 radians = 15.6 arcsec. Achieving acceptable results probably needs the camera to be static at the scale of ~5 arcsec. This is achievable but considerable care is needed.
On the whole, 16 Mp is enough for me...