I keep my gear in Pelican/Storm hard cases - I have several, all stored in the den closet. My 'go to' kit for around the house shooting, 5DII with 24-105mm and a 430EX II, are in the small Storm im2075. My next most-used set of lenses is in the easy-to-grab Storm im2300 - the 70-200mm f/2.8L IS II and several primes (35L, 85L II, 100L Macro, and 135L). Less frequently used gear is in the large Pelican 1600 - 7D, 16-35L II, 17-55mm, TS-E 24L II, MP-E 65, 100-400, 1.4x II and 2x II TCs, MT-24 EX, second 430EX II, etc. The Storm im25000 carryon case is empty except when I'm traveling with it.
I like the security of keeping the gear in waterproof hard cases - pipes can burst, etc., plus I have a pair of curious toddlers. The gear is also kept free of dust, and dry during the humid New England summers (I keep desiccant packs in each case, the color-changing type to indicate when they need to be replaced.