A shot I took last year in California. It was the middle of the night, and the house next to the one I was staying caught fire. We went outside, and I started taking pictures with my 24-105. I could have used a faster lens but I needed the versatility of the zoom. I just cranked the ISO to 6400 on my 5D2. I have shots with the whole house on fire but the one I most like is his one. fire fighters
BTW, nobody was hurt, this was an old house in an expensive neighborhood. The owner did not have insurance but he sold the lot and probably got enough money to move to a more modest neighborhood.