As has already been said, for close up work or scenes with both distant and close objects, you will get parallax errors and "ghosting" of the objects if you don't use a panoramic head and the correct nodal point. So indoor scenarios more-or-less demand a proper setup. I use the RRS (Really Right Stuff) head and find it awesome to use.
But just as important to note, even if you use the best possible setup and have all the nodal points for your body and lens combinations, to get optimal results you must use fully manual setup in the camera - manual focus, manual white balance, and manual setting (not Av or Tv). Prepare the settings off the part of the image you want perfectly exposed (the rest will generally be very close, but may be slightly over- or under-exposed in a stand-alone image) and you will have far less post-processing issues, and the quality of the final image will be improved. If you don't do this, you can end up with light banding and areas of softness in the overlapping regions.
If I'm doing landscapes with only distant objects, I will occasionally do hand-held panoramas as the "errors" are far less obvious, but I still use a fully manual setup in the camera.
Hope this helps.