The bulk of my business involves photographing moving boats - usually from other moving boats.
Because of the conditions I work in, I need weather-sealed cameras. I generally use the 1DS and sometimes 1D bodies and most of the time need a long lens. The larger sensor makes the 300mm the most useful lens for me.
I've owned two copies of the 2.8 L over the past 20 years. They both have been outstanding performers. Many times, though, I'll need a little more reach, so I have to resort to glass in the 400 to 600 range. Frequently, I'll use a teleconverter, the later versions of the EX 1.4x trade off very little other than a stop of speed, but once in a while a 400/2.8 or 600/4 is needed. By the end of a long day, I certainly feel I've gotten a good workout.
So, my hat is off to anyone who can successfully use these "big guns". The good news is, after working with one over a couple days, it kind of makes using a 300/2.8 child's play.