I’ve only noticed LR 4.3 running painfully slow just recently, I’ve done heaps of searching but nothing people were recommending was fixing it, so I thought, what have I changed in the last month, then I remembered that I installed a new anti-virus, (bitdefender), where previously I was using AVG, so I uninstalled it, LR is now running perfect.
Not sure if this will work for everyone, but it might be worth a try.