If you use Lightroom, you are always editing in Prophoto. Generally, you would want to edit in a wide color space before you throw away color information by converting to SRGB, however, you do need to make sure you understand what is happening when you convert to SRBG, the processor is using the closest SRGB color to substitute for the ones that are out of gamut, and sometimes the result is just plain awful.
However, if your camera is set to SRGB, it doesn't matter all that much, since it has already done the conversion. Pro photo will not change the colors, it just uses what you feed it.