With the 50L I had to shoot without a flash (none allowed in the nursery) so I opened it up to about f/2 and ISO 2000 right on the baby's body, focusing on the face, and the results were absolutely fantastic. I am very pleased with that lens. Outside with low ISO I play it safer with my 1Ds III and 50 f/1.4. The color saturation seems to be better in low light/indoors for the 50L vs. the 1.4. Nice lens for sure.
Overall, I think the 24L, 35L, 50L, 85L, 135L, and 200L, if you can afford all of that, would be the world's best set of lenses out of all companies up to 200mm.