Thanks, exphose. I had also written a Perl script that copied large files to the card until it was filled. Didn't run into any issues with the card. That, of course, doesn't rule out weird interactions between the card and camera.
But I'll note that I've not seen the issue with the replacement 1DX I have (knock on wood) using the same cards I had before -- I've even filled them up during a shoot.
Shawn L.