I use the old 400/5.6 mostly to shoot birds in flight. Being unpredictable, the pan motion can be side to side, up and down, or anything in-between. So, IS is not that useful for these shots. Setting IS to horizonal pan mode would sometimes be applicable, but not predictable in the field from shot to shot. I have found the old 400 on 5D II to focus fairly quickly. You usually have to follow the flight path for a few seconds in AI servo before getting framing right in any event.