I don't know if you have checked these out but in my opinion the NatGeo bags are the coolest, fantastic quality. I'm speaking more preciselly about the backpacks. I have th NG 5162 (medium- not too big, not to small just perfect) and I can fit:
On the "photo compartment"
-5D III with 4 Primes (Zeiss ZE type, not the smallest ones) or 3 primes and my 70-200 f4 but the 70-200 doesnt fit with the camera attached, no biggie for me. The large model probably fits bigger teles and more stuff.
-Macbook Air 13" (in the rear PC compartment, can even also fit some magazines there when travelling)
-filters, batteries, cards, remote shutter, cleaning stuff, WD Passport 1TB hard drive, Colorchecker passport etc etc
Just fantastic. With all this loaded still has some space to put a travellers bag with your personal items inside (toothpaste, shaving stuff etc), a couple of T-shirts, sunglasses, keys, wallet etc etc. And in case you don't bring your photo equipment you can transform it into a classical backpack by removing the "photo compartment" by unzipping internally and removing the lens separators.
Check them out, they also have more "street style" bags for wondering around cities:http://www.geographicbags.us/earth-explorer-collection