Remember, as jpegs, even saved with a compression setting of 10 (little compression), it is what it is, compressed. You may be losing some, albeit, minimal information and also jpegs also flatten, so if you use photoshop or lightroom or such and make a lot of layers, jpegs will flatten it all. You will be able to save more jpegs than you will tiff, but that is the tradeoff... Tiff, unlike what others have said, is not an obsolete file type, however, it isn't as well packaged as lets say a psd or dng. The problems with psd or dng, unless you have a program that can read it, you may not be able to show it or work with it on another computer. That isn't as vital as it was in the past, but if you have clients with older windows machines and you have psd files and hope to show them your images, they may not be able to open them. Tiffs are not compressed, can be opened on windows and macs, even without photoshop or another image editing program installed on it, especially on older systems. When I shoot for clients, unless i know they have photoshop, I only give them Tiff's and Jpegs of my files when I'm done with them. Tiff for the full sized and a smaller jpeg so they can throw it on the web, proof, or do whatever with. If money and space isn't an issue, save in tiff or psd (if it's only for you), or if space is an issue, save in the highest jpg possible and save up for a new bigger HD.