+1 for 2.8 (for sharpness). But I don't think most people buy this lens for it's slight increase in sharpness at that aperture as there are plenty of other much more affordable options that will give you similar results at 2.8 (like others have mentioned). What you get from the 50L is a good, accurate tool to produce the "look" of a large aperture lens while remaining sufficiently sharp near the wide open end (not to mention the color rendition, contrast, etc etc).
Similar to Dylan777, I shoot slightly stopped down usually lingering around 1.4-2.0. This yields about a 90% hit rate for me and provides the desired meeting between sharpness and bokeh.
If one insists on scrutinizing images at 100%, reading MTFs, etc, finding slight differences in sharpness will be a given. Even then, you may have to look pretty hard to see it. For most of the shots I get from the 50L (at said apertures), the level of sharpness from 1.4-2.0 does not vary a whole lot when viewing at typical screen/print sizes.