Eh, this looks like motion blur. Not one thing is in focus, even in what you can obviously see is the focus field. Don't see glare (as if from moisture in the lens).
A few things:
1/20th is waaaay too slow a shutter speed if you're shooting over 70mm...tripod or not. In cinema, even on a 50lb, $20,000 tripod, we never start action until a few seconds after rolling, as you need time for the camera to settle. Remote or not, the mirror flip in a DSLR causes vibration...even when it's locked up, the shutter itself will cause minor vibration. If you're ever in California, like me, you know that there's no such thing as "stable ground". Don't ever count on it. When I shoot long exposures, I always hold a black card in front of the lens before the shutter opens, wait a second, then open it up for exposure...camera shake is a sneaky beast.
125 ISO is way too low. Boost it and increase your shutter speed. Canon sensors seem to be the least noisy in increments of 160, so the cleanest ISOs are 160, 320, 640, etc, so actually 640 will probably have less noise than 125, oddly. There is virtually no significant visible noise until you get past 800...I think even 1250 is very pristine, and better than many of the lower ISOs. Go up to 640 or 800, increase your shutter speed...1/500 and above are pretty safe.
Doesn't really look like a glass issue, but do make sure your filters are awesome. I don't know what you've got on there. L lenses are brilliant and expensive...but the g's you spend on 'em are worthless if you have a murky $25 dollar Japan Optics plexi-glass filter in front of it. B+W/Schneidder filters are immaculate. They're painfully expensive, but they are sharp as a tack and they disappear in front of your lens. I've had a $120 B+W filter take the fall on a volcanic rock in New Zealand for my $1600 L lens, and saved its life. It's like an insurance policy.
Hope this helps. Sloth hates fuzzy images.
