On my honeymoon I travelled with my 5DIII, 17-40L, 35L, 135L, and extenders. I can't tell I had troubles carrying this around all day, as I've been a professional athlete for some long time of my life, but maybe others may feel the weight after few hours.
Anyway, if I had your gear, I would pick the 24L and the 100L for a 2 lens setup. If your wife enjoys being photographed, you may consider adding the 50L, or replacing the 100L with the 85L, and have your 2 lens setup to be the 24L and 85L.
If spending money on extra stuff won't bother you, then go for the Fuji X system and leave your Canon gear at home. As I'm not really that rich, I prefered to make use of what I have, and save the money to be spent during the trip itself.
Good luck, and congrats!