Answer is plain and easy : yes, it can ! And I know the effects firsthand :-(
Some would say it looks like one of these Wile.E Coyote cartoon ... but recipe is easy... wanting to experiment with Photography can be tempting....
Take somebody who is a bit light sensitive (years in Texas with probably poor grade sunglasses didn't help), have fun at night with photo friends for a "lighpainting session" (ie. taking picts with lights effects at night), and fire a 430EX external flash at your face from 30-40cm below, and don't close your eyes ....
=> result is really cool "ghost like picture" like in the books (ie. your camera set on long exposure takes picts with 3 times your face for example if you move and redo it, just the face that was under flash exposure, rest of the body is invisible and you see the background thru ...), but better if you close your eyes and/or look up instead of looking in front or worst, low at your flash (like the first tries to see where to position it best, etc ...)
=> side effect after multiple attempts in the evening is darker spot in your eyes, showing "paler" zones when looking at lights (and having focus shift left/right) as if you had a water spot on the eye diffracting light a bit, and showing "greyer" areas when looking at uniform white wall (or blue sky) with high luminosity ...