Haven't read all 5 pages, so forgive me if it has already been mentioned.
IQ is limited by the weakest link. That is the lens, assuming you shoot on tripod, mirror lock-up, cable release etc. If you compare a small crop sensor body with a large sensor body, but use a bad lens, you will not see any improvements, because the lens if limiting the potential of the large sensor with small pixels.
The important thing is also not MP count, but pixel size. So that limitation already applies on 20 MP crop sensor bodies that today have the same pixel dimensions as the 5dsr. There are very few lenses than can resolve those pixels. Look a bit more at the microscopy literature, particularly on "empty magnification", which is analogous to small pixels. Higher magnification/more pixels are not giving you more information, but only enlarged/detailed blur circles. Also check out Airy disks under optics. MF bodies with 50 MP backs have much lager pixels sizes, so have a distinct advantage in this respect. Both for resolution/sharpness, as well as tonality and shadow noise.
Bottom line: you want to take advantage of a 50 MP dSLR body, forget about zoom lenses. Some of the best prime glass money can buy may just about be sufficient.
The downsampling of a 50 MP to a 20 MP file and comparing it to a 20 MP capture most likely does give you a better image, as mentioned by another person. You can do rough image adjustments on the 50 MP file, and tonality gets much smoother on the 20 MP resize, even if you edit in 16 bit/channel.
my 389'900 cents