I am a very happy RF 100-500mm user, as evidenced by the number of shots with it and the RF 1.4x and 2x I’ve posted. But that Nikon 500mm f/5.6 PF is the best lightweight lens I‘ve owned and I’d rather buy the Canon equivalent of it than a 400/4 even if they could reduce the weight right down. The range with TCs of 500-700-1000mm (like on the 100-500mm too) is more useful to me than 400-560-800mm. My 400mm DO II spent most of its time with a 1.4 or 2xTC on it.
I reckon the new 400/4 will be popular if they can make it even more compact, and no doubt performance is going to improve significantly with the RF converters as well, so it may work with a higher pixel density APS-C body as well.
It could be a more serious alternative to the 400/2.8 with the upcoming mirrorless cameras with more advanced AF systems.
There is also the rumoured 200-500/4 to replace the 200-400/4 + 1.4x, looks like a pretty significant upgrade if they make it.
Strangely, Nikon doesn't seem to at least refresh the 500/5.6 for the Z-mount. There was also a patent for a 600/5.6, I hope their 200-600/5.6-6.3 will be excellent, but it's not nearly the same thing and they have quite a way to go just to release all that's still blacked out on their roadmap.
I kind of like the 800/11 for what it is (great to start with and it can't be any smaller and lighter than it is), but it needs a second body to work because of the MFD and fixed aperture (and the great 100-500/4.5-7.1 + 1.4x may be a straight up replacement, but the zoom limitation with the teleconverters is annoying, especially for the money), and they said they are considering more lenses like this, so I wouldn't mind if they could expand the range and do a 1000/11 as well, although it looks like that 1200/8 is what they are going for instead if that's what they've meant by that statement.
If it minimises the shortcomings with mirror lenses, it could be really good., but it won't be that cheap. and again with a fixed aperture, so I wonder how is the DOF, it is already marginal with the 800/11 at its ideal range of 6-12 meters for birds.