Full disclosure, I have not used either. I have both the EF 85/1.4L IS and the EF 100/2.8L Macro IS. Generally, I'd take an 85/2 over a 100/2.8 for portraits, but my main portrait lens is the RF 70-200/2.8 (which replaced my EF 70-200/2.8 II). I may switch my EF 85/1.4 for the RF 85/1.2 at some point. I don't plan to get the RF 100L Macro, primarily because of the focus shift issue with the lens.