Well, let me see here.
I have a 20D, and my longest lens (aside from my telescope) is my 70-200/2.8L IS Mark I with stacked 1.4x teleconverters. That combo performs very well at it's optical peak of f/9.
Just a couple of days ago, B&H has the 70-200/2.8L IS Mark II for $1,974. I thought very seriously about jumping on it, primarily for it's ability to perform well with stacked 1.4x and 2x teleconverters on an 18MP 1.6-crop sensor. I didn't, however, because no Canon body with that sensor could AF with that combination.
My goal is basically 2x more real resolving power than I have now, with the same handholdability and while retaining fast AF (basically, near diffraction-limited with AF). I have 8.2MP and 400mm, so 16.4MP and 560mm would do it, or 32.8MP and 400mm would do it (assuming sufficient optical quality in both cases). Well, with the loss of f/8 AF sensors on the 1D line, it seems like the only hope is for a ton of pixel density. 24MP and 400mm would get me about 70% more real resolution than I have now, and maybe that would be enough to make me spend all those thousands of dollars, maybe not, by 18MP and 400mm wasn't, even with the $400 off a couple of days ago.
So, yes, bring on the pixel density, and bring on the flexible video crop options - they're handy with astrophotography and in other special cases.