Yes, that is the tradeoff - more pixels, but when you start cranking the ISO, the noise creeps in. NR generally cuts down resolution and fine detail, though some of these newer NR schemes seem to do pretty good, as long as your computer has the horsepower to use it.TBH, once you start going up in iso or narrower in aperture, the 17mpx of the R5/RFii resolves detail as well as the 32Mpx of the R7 because of noise and diffraction, although the R7 does put more pixels on the target. To get the best out of the R7, you need an f/4 lens or wider. Having said that, I have got good images from the R7 with the RF 800/11 in decent light.
It'd be nice to have an R7 II with another full stop of lower noise, that is, ISO 6400 looking like ISO 3200 on today's body. Not sure that such a dramatic improvement is possible, at least not in RAW noise. There is only so much light available.
This does illustrate the problem with long, slow lenses. 800 at f/11 is just not bright enough outside of very bright skies or full sun. So photographing warblers in the dark forest becomes much more difficult. Ditto the f/7.1 of the 100-500. Not quite as bad, but it is decidedly darker than I'd like.
But size matters, as does price. I used to have a 500 f/4L II, and while it was a stellar lens, it was not a walkabout lens by any stretch. It sat in the safe most of the time I owned it.
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