tron said:
25-50 is really too much unless you mean 25 for luminance and 50 for color. Even with 25 in luminance you lose sharpness a little. OK you may tweek the sharpness settings but still. Having said that I use these settings too for my highest iso shots but I am comparing apples to oranges since I do not refer to shooting in the dark pictures but action ones. Also many report that 6DII files can be cleaned nicely in PP so yes you have a point. Could you please elaborate more about your noise handling settings by the way?
Right: generally, on midrange-ISO shots I like 25 luminance, 50 color, and recover a bit more sharpness with a tiny bit sharpening, because you can control the edges there. On ISO 400 and below, luminance will be between 0-20. Color is generally pretty non-destructive to detail, so it's just whatever looks good for the shot.
On photos that are higher ISO and have undesirable grain -- obviously depending on the subject -- up to 50 luminance, but that will appear obviously artificially sharpened. It happens with wildlife shots where there was no choice because of available light, and I where I don't have many photos of that bird or other animal.
But basically, there are photos I really care about and the infinite number of other ones. On the small number of photos I really care about, it's different for every photo (or set) anyhow. I start with color, get it where I want it, play with luminance sliders, and then finish with sharpness, often going back to luminance.